Sphaerosporidosis
Agent	Sphaerospora sp.
Hosts	Most freshwater species, esp. cyprinids.
Location	Glomeruli, tubular lumen and interstitium.
Type of lesion	Diffuse haematopoietic necrosis and haemorrhage (presporogonic stages). Destruction of glomerular capillaries, dilatation of Bowman's space, thickening of Basement membrane and haemorrhage (sporogonic stages and developing pseudoplasmodia). Dilatation of tubules and flattening of epithelium (sporogonic stages).
Special features
Diagnosis	Characteristic lesions in tissues SBA lectin may he used to demonstrate Sphaerospora sp. in tissues. Important differential diagnosis are PKD, toxic damage.

Sphaerospora renicola in Cyprinus carpio kidney, H&E.

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