Mycobacterial infection ("Fish tuberculosis") and Nocardiosis
Agent	Mycobacterium fortuitum, M. marinum and Nocardia spp.
Hosts	Most fish species incl. aquarium fishes.
Location	Kidney interstitium.
Type of lesion	Multifocal, chronic, granulomatous. Multinucleated giant cells.
Special features	Intracellular. Stains poorly with H&E.
Diagnosis	Demonstration of acid-fast bacteria in lesions, isolation of the agent. Differential diagnosis are BKD and fungal nephritis.

ZN staining of Atlantic salmon
kidney showing few bacteria.

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